Mitochondrial / metabolic support
MOTS-c — the mitochondria-derived peptide for metabolic resilience.
About this protocol
A premium add-on built around MOTS-c — a mitochondria-derived peptide encoded in the mitochondrial genome itself. Studied for metabolic regulation, exercise adaptation, and cellular resilience. One of the most recently characterized peptides in the longevity space.
Who it's for: Adults focused on cellular energy, metabolic flexibility, and exercise-supported longevity.
What's in this protocol
MITOCORE is built around a single compound:
MOTS-c
Mitochondrial Open Reading Frame of 12S rRNA-c
Encoded in the mitochondrial genome itself. Activates AMPK pathways — the master regulator of cellular energy sensing — promoting metabolic flexibility, insulin sensitivity, and stress resilience. Translocates to the nucleus under stress to regulate gene expression.
Used for
What members are working toward
The following reflects areas of interest commonly reported by members and studied in the clinical literature. Results depend on individual health status, labs, and physician-directed care. Nothing below constitutes a treatment claim.
Mitochondrial signaling
MOTS-c is one of the few peptides directly encoded in mitochondrial DNA — a unique signaling pathway distinct from nuclear-encoded peptides.
Insulin sensitivity
Activates AMPK pathways involved in glucose homeostasis and metabolic flexibility — relevant for members whose metabolic markers indicate insulin resistance trajectory.
Exercise adaptation
Studied for its role in supporting the metabolic adaptations associated with consistent training — particularly relevant in the longevity-by-movement model.
Premium tier-agnostic add-on
Bills separately from your monthly tier and stacks on top of any base protocol. Available at Foundation, Optimizer, or Elite with clinical eligibility.
Relevant bloodwork markers
MITOCORE is prescribed and monitored against bloodwork. The Halftime Baseline panel ($249, separate onboarding deliverable) covers the relevant markers below.
Aligned intents
MITOCORE is most commonly chosen by members whose primary intent is one of:
How to subscribe
Available at every tier
MITOCORE is a premium add-on — it bills separately on top of any tier (Foundation, Optimizer, or Elite) with clinical eligibility. It doesn't count toward your monthly protocol total.
Premium add-ons (VITALIZE, IMMUNE GUARD, MITOCORE) bill separately on top of any tier. The Halftime Baseline bloodwork panel ($249) is a separate onboarding deliverable, available at any tier.
Join the waitlistLaunching July 1, 2026
All prescriptions require physician evaluation. Compounded medications are not FDA-approved. Individual results vary. This is not medical advice.